Vitamin D in Ulcerative Colitis:
A Cause or an Effect?
Published: August 1, 2012 | DOI: https://doi.org/10.7860/JCDR/2012/.2319
Taghi Amiriani, Somaye Barzanoni, Sima Sedighy, Sima Besharat, Fatemeh Nejadi Kelarijani, Hamidreza Joshaghani, Gholamreza Roshandel, Hamide Akbari
1. Gastroenterologist, Assistant Professor, Golestan University
of Medical Sciences, Golestan Research Center of
Gastroenterology and Hepatology.
2. Medical Doctor, Golestan University of Medical Sciences.
3. Rheumatologist, Assistant professor, Golestan University of
Medical Sciences.
4. Researcher, Golestan Research Center of Gastroenterology
and Hepatology, Golestan University of Medical Sciences.
5. Medical Doctor, Golestan University of Medical Sciences,
Golestan Research Center of Gastroenterology and
Hepatology.
6. PhD of Clinical Biochemistry, Associated Professor,
Golestan University of Medical Sciences, Golestan
Research Center of Gastroenterology and Hepatology.
7. Researcher, Golestan University of Medical Sciences.
8. Internal Medicine Specialist, Golestan University of Medical
Sciences.
Correspondence
Dr. Sima Besharat
3rd Floor, Shahid Nabavi polyclinic,
4th Azar Alley, 5-Azar St, Gorgan City,
Golestan province, Iran.
Phone: 0098-171-2240835
E-mail: besharat@goums.ac.ir
Background and Aims: Vitamin D deficiency is common among patients with inflammatory bowel disease, even when the disease is in remission. This study was designed to evaluate the serum levels of 25-hydroxy vitamin D [25(OH)-D3] in patients who suffered from ulcerative colitis and the control group in Golestan province in the northeast of Iran.
Methods: In this case-control study, 60 patients with a definite histopathological diagnosis of ulcerative colitis were included. The control group was selected from healthy blood donors. The serum levels of 25(OH)-D3 were measured by the ELISA method (ids- UK). Data were entered into the SPSS-16 software and were analyzed by t-test and Chi-square test.
Results: The mean serum level of vitamin D in the patients was significantly lower as compared to that in the control group (P-value <0.01). The differences in the levels of 25-OH-D3 were statistically significant between the two sexes, in both groups. A normal vitamin D level was seen in all cases with proctitis, in 20% of cases in the rectosigmoiditis group and in no cases in the pan-colitis group. The difference was statistically significant (p-value <0.01).
Conclusions: It can be concluded that the serum levels of vitamin D in the patients with ulcerative colitis are low and that inflammatory bowel disease can be a target for the specific vitamin D therapy.
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